Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
HSF4 heat shock transcription factor 4	CTM , CTRCT5	Homo sapiens	15	protein-coding	HSF5 , HSFX4 , HSFX3 , HSFX2 , HSFY2 , HSF2 , HSF1		602438

Summary

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0003700	enables DNA-binding transcription factor activity	IBA

Component (4)

Go ID	Value	Evidence
0000785	located_in chromatin	IDA
0000785	located_in chromatin	ISA
0016607	located_in nuclear speck	IDA
0005634	is_active_in nucleus	IBA

Process (3)

Go ID	Value	Evidence
0070306	involved_in lens fiber cell differentiation	ISS
0000122	involved_in negative regulation of transcription by RNA polymerase II	IDA
0006357	involved_in regulation of transcription by RNA polymerase II	IBA

Gene Loss events - HSF4 (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_LWZPIL	Chrysochloris asiatica	Afrosoricida	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004