Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| CHRNB2 cholinergic receptor nicotinic beta 2 subunit | EFNL3 , nAChRB2 | Homo sapiens | 7 | protein-coding | ZACN , HTR3B , HTR3A , CHRNA9 , HTR3C , HTR3D , HTR3E , CHRNA10 , CHRNG , CHRNB1 , CHRND , CHRNE , CHRNB4 , CHRNB3 , CHRNA5 , CHRNA3 , CHRNA6 , CHRNA4 , CHRNA1 , CHRNA2 , CHRFAM7A , CHRNA7 , GABRE , GABRG3 , GABRG1 , GABRG2 , GABRA2 , GABRA3 , GABRA5 , GABRA1 , GABRA4 , GABRA6 , GABRD , GABRQ , GABRP , GABRB1 , GABRB3 , GABRR2 , GABRR3 , GABRR1 , GABRB2 , GLRB , GLRA2 , GLRA1 , GLRA3 | 118507 |
Summary
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]
GeneOntology
Gene Loss events - CHRNB2 (1 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_317GVR | Galeopterus variegatus | Dermoptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |