Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
NGB neuroglobin		Homo sapiens	4	protein-coding			605304

Summary

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005092	enables GDP-dissociation inhibitor activity	IDA

Component (2)

Go ID	Value	Evidence
0005829	located_in cytosol	TAS
0005759	located_in mitochondrial matrix	IEA

Process (4)

Go ID	Value	Evidence
0071456	involved_in cellular response to hypoxia	IMP
0015671	involved_in oxygen transport	IBA
0015671	involved_in oxygen transport	NAS
0001666	involved_in response to hypoxia	IBA

Gene Loss events - NGB (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_28CXIP	Erinaceus europaeus	Eulipotyphla	Gene deletion	Full	No	10.1093/icb/icy004
GL_HXGFDH	Manis javanica	Pholidota	Gene deletion	Full	No	10.1093/icb/icy004
GL_W1IFBM	Carlito syrichta	Primates	Gene deletion	Full	No	10.1093/icb/icy004
GL_ZTD6HM	Sorex araneus	Eulipotyphla	Gene deletion	Full	No	10.1093/icb/icy004