Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
MRGPRX2 MAS related GPR family member X2	MGRG3 , MRGX2	Homo sapiens	4	protein-coding	GPR152 , MRGPRF , MRGPRG , MRGPRE , MRGPRX4 , MRGPRX3 , MAS1L , MRGPRX1 , MRGPRD , MAS1		607228

Summary

Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IBA

Component (2)

Go ID	Value	Evidence
0016020	located_in membrane	IC
0005886	is_active_in plasma membrane	IBA

Process (6)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IBA
0045576	involved_in mast cell activation	IDA
0043303	involved_in mast cell degranulation	IDA
0032467	involved_in positive regulation of cytokinesis	IMP
0019233	involved_in sensory perception of pain	NAS
0030431	involved_in sleep	NAS

Gene Loss events - MRGPRX2 (5 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0MMFAR	Orcinus orca	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_24SS4H	Physeter catodon	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_4ZBLA2	Hippopotamus amphibius	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_KE20VO	Balaenoptera acutorostrata	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_SCIOVS	Tursiops truncatus	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057