Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TAS2R31 taste 2 receptor member 31	T2R31 , T2R44 , T2R53 , TAS2R44	Homo sapiens	1		TAS2R13 , TAS2R14 , TAS2R9 , TAS2R36 , TAS2R33 , TAS2R19 , TAS2R20 , TAS2R50 , TAS2R45 , TAS2R43 , TAS2R30 , TAS2R46 , TAS2R10 , TAS2R42 , TAS2R8 , TAS2R7 , TAS2R38 , TAS2R3 , TAS2R4 , TAS2R5 , TAS2R1 , TAS2R41 , TAS2R60 , TAS2R16 , TAS2R40 , TAS2R39		612669

Summary

TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IEA

Component (3)

Go ID	Value	Evidence
0016020	is_active_in membrane	IBA
0016020	located_in membrane	IC
0005886	located_in plasma membrane	TAS

Process (3)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IEA
0001580	involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA
0001580	involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA

Gene Loss events - TAS2R31 (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_QJI6UX	Macaca mulatta	Primates	LOF (frameshift, premature stop, ss)	Full	No	10.1093/molbev/msi027