Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
HSPA6 heat shock protein family A (Hsp70) member 6	HSP70B'	Homo sapiens	1	protein-coding	HSPA13 , HSPA14 , HSPA2 , HSPA8 , HSPA7 , HSPA1L , HSPA1A , HSPA1B , HSPA5 , HSPA9		140555

Summary

Enables enzyme binding activity; heat shock protein binding activity; and unfolded protein binding activity. Involved in cellular response to heat and protein refolding. Located in centriole and cytosol. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (11)

Go ID	Value	Evidence
0008180	part_of COP9 signalosome	IDA
0072562	located_in blood microparticle	HDA
0005814	located_in centriole	IDA
0005737	is_active_in cytoplasm	IBA
0005737	located_in cytoplasm	IDA
0005829	located_in cytosol	IDA
0070062	located_in extracellular exosome	HDA
0005576	located_in extracellular region	TAS
1904813	located_in ficolin-1-rich granule lumen	TAS
0005634	is_active_in nucleus	IBA
0034774	located_in secretory granule lumen	TAS

Process (7)

Go ID	Value	Evidence
0070370	NOT involved_in cellular heat acclimation	IMP
0034605	involved_in cellular response to heat	IDA
0034605	involved_in cellular response to heat	IMP
0051085	involved_in chaperone cofactor-dependent protein refolding	IBA
0042026	involved_in protein refolding	IBA
0042026	involved_in protein refolding	IDA
0006986	involved_in response to unfolded protein	TAS

Gene Loss events - HSPA6 (5 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_5GFJKA	Hippopotamus amphibius	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_BKFOJQ	Physeter catodon	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_M50UBB	Balaenoptera acutorostrata	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_N6CIS8	Tursiops truncatus	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_XSVEJP	Orcinus orca	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057