Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
CES4A carboxylesterase 4A CES6 , CES8 Homo sapiens 16 protein-coding ACHE , CES1 , CES3 , CES5A , CES2 3.1.1.-

Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]

GeneOntology

Gene Loss events - CES4A (5 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_0KXBSF Tursiops truncatus Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_BG4FLM Hippopotamus amphibius Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_HAU68N Physeter catodon Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_MZRVMO Balaenoptera acutorostrata Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_ODY8H9 Orcinus orca Artiodactyla Other Full No 10.1016/j.cub.2021.02.057