Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
CES3 carboxylesterase 3 ES31 Homo sapiens 14 protein-coding ACHE , CES4A , CES1 , CES5A , CES2 3.1.1.1 605279

Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

GeneOntology

Gene Loss events - CES3 (5 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_2FJKRZ Balaenoptera acutorostrata Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_2NMBVB Tursiops truncatus Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_82K63V Physeter catodon Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_A81FBU Orcinus orca Artiodactyla Other Full No 10.1016/j.cub.2021.02.057
GL_NPGKPJ Hippopotamus amphibius Artiodactyla Other Full No 10.1016/j.cub.2021.02.057