Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
KRT71 keratin 71	HYPT13 , K6IRS1 , KRT6IRS , KRT6IRS1	Homo sapiens	10	protein-coding	KRT8 , KRT6C , KRT6B , KRT6A , KRT80 , KRT74 , KRT72 , KRT73 , KRT77 , KRT78 , KRT4 , KRT79 , KRT76 , KRT3 , KRT2 , KRT1 , KRT75 , KRT5 , KRT85 , KRT86 , KRT81 , KRT83 , KRT84 , KRT82 , KRT7		608245

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005515	enables protein binding	IPI

Component (5)

Go ID	Value	Evidence
0005829	located_in cytosol	TAS
0070062	located_in extracellular exosome	HDA
0045095	is_active_in keratin filament	IBA
0045095	located_in keratin filament	IDA
0045095	located_in keratin filament	IPI

Process (4)

Go ID	Value	Evidence
0031069	involved_in hair follicle morphogenesis	IMP
0045109	involved_in intermediate filament organization	IBA
0045109	involved_in intermediate filament organization	IMP
0031424	involved_in keratinization	IBA

Gene Loss events - KRT71 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0PBAVR	Orcinus orca	Artiodactyla	Other	Full	No	10.1186/s12983-017-0225-x
GL_37N0NQ	Neophocaena asiaeorientalis asiaeorientalis	Artiodactyla	Other	Full	No	10.1186/s12983-017-0225-x
GL_SNXMOR	Lipotes vexillifer	Artiodactyla	Other	Full	No	10.1186/s12983-017-0225-x
GL_YV1PXJ	Balaena mysticetus	Artiodactyla	Other	Full	No	10.1186/s12983-017-0225-x