Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
KRT31 keratin 31	HA1 , Ha-1 , hHa1 , KRTHA1	Homo sapiens	7	protein-coding	BFSP2 , KRT18 , KRT24 , KRT23 , KRT33B , KRT34 , LOC100653049 , KRT33A , KRT40 , KRT38 , KRT37 , KRT39 , KRT35 , KRT32 , KRT36 , KRT19 , KRT27 , KRT28 , KRT25 , KRT26 , KRT10 , KRT12 , KRT17 , KRT20 , KRT16 , KRT14 , KRT9 , KRT15 , KRT13		601077

Summary

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005515	enables protein binding	IPI

Component (5)

Go ID	Value	Evidence
0005856	is_active_in cytoskeleton	IBA
0005829	located_in cytosol	TAS
0070062	located_in extracellular exosome	HDA
0005615	located_in extracellular space	HDA
0005882	located_in intermediate filament	IEA

Process (3)

Go ID	Value	Evidence
0008544	involved_in epidermis development	TAS
0030855	involved_in epithelial cell differentiation	IBA
0045109	involved_in intermediate filament organization	IBA

Gene Loss events - KRT31 (2 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0MKCQX	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1186/1471-2164-15-869
GL_DNQV0U	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1186/1471-2164-15-869