Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TAS2R3 taste 2 receptor member 3	T2R3	Homo sapiens	1	protein-coding	TAS2R16 , TAS2R60 , TAS2R41 , TAS2R30 , TAS2R36 , TAS2R33 , TAS2R19 , TAS2R20 , TAS2R50 , TAS2R45 , TAS2R43 , TAS2R31 , TAS2R46 , TAS2R10 , TAS2R8 , TAS2R13 , TAS2R14 , TAS2R9 , TAS2R42 , TAS2R7 , TAS2R4 , TAS2R38 , TAS2R5 , TAS2R1 , TAS2R40 , TAS2R39		604868

Summary

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IEA

Component (3)

Go ID	Value	Evidence
0016020	is_active_in membrane	IBA
0016020	located_in membrane	IC
0005886	located_in plasma membrane	TAS

Process (3)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IEA
0001580	involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA
0001580	involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA

Gene Loss events - TAS2R3 (8 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_IKVZJA	Kogia sima	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_LUFDS7	Hippopotamus amphibius	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1186/s12862-014-0218-8
GL_MXXKTL	Delphinus capensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_QXLBGY	Neophocaena phocaenoides	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_RTGNWC	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_W0FIKQ	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_WHZO9U	Sousa chinensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8
GL_YPZAPA	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1186/s12862-014-0218-8