Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TRIM34 tripartite motif containing 34	IFP1 , RNF21	Homo sapiens	9	protein-coding	TRIM55 , TRIM63 , TRIM54 , TRIM35 , BSPRY , TRIM13 , RNF39 , TRIM75 , TRIM61 , TRIM60 , RFPL4B , TRIM58 , TRIM21 , TRIM77 , TRIM17 , TRIM64B , TRIM64 , TRIM64C , TRIM4 , TRIM43 , TRIM43B , TRIM6 , TRIM5 , TRIM49B , TRIM49C , TRIM49 , TRIM51G , TRIM51 , TRIM49D2 , TRIM48 , TRIM22 , TRIM11 , MEFV , RFPL2 , RFPL3 , RFPL4A , TRIM68 , TRIM38 , TRIM39 , TRIM62 , TRIM74 , TRIM73 , TRIM50 , TRIM14 , TRIM72 , TRIM69 , TRIM15 , TRIM10 , TRIM26 , TRIM27 , TRIM7 , TRIM40 , TRIML2 , TRIML1 , TRIM41 , TRIM31 , TRIM52	2.3.2.27	605684

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0042802	enables identical protein binding	IPI

Component (6)

Go ID	Value	Evidence
0005737	is_active_in cytoplasm	IBA
0005737	located_in cytoplasm	IDA
0005829	is_active_in cytosol	IBA
0005829	located_in cytosol	TAS
0005739	located_in mitochondrion	IEA
0005654	is_active_in nucleoplasm	IBA

Process (9)

Go ID	Value	Evidence
0051607	involved_in defense response to virus	IEA
0045087	involved_in innate immune response	IBA
0051091	involved_in positive regulation of DNA-binding transcription factor activity	IDA
0051092	involved_in positive regulation of NF-kappaB transcription factor activity	IBA
0010508	involved_in positive regulation of autophagy	IBA
0043123	involved_in positive regulation of canonical NF-kappaB signal transduction	IBA
0000209	involved_in protein polyubiquitination	IBA
0032880	involved_in regulation of protein localization	IBA
0046596	involved_in regulation of viral entry into host cell	IBA

Gene Loss events - TRIM34 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_EHONDE	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_KWYVBT	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_MAJUCQ	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_YROTGI	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671