Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
THRSP thyroid hormone responsive	S14 , Lpgp , THRP , LPGP1 , SPOT14	Homo sapiens	2	protein-coding			601926

Summary

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0042802	enables identical protein binding	IPI

Component (4)

Go ID	Value	Evidence
0005829	is_active_in cytosol	IBA
0005829	located_in cytosol	ISS
0005829	located_in cytosol	TAS
0005654	located_in nucleoplasm	IDA

Process (5)

Go ID	Value	Evidence
0006629	involved_in lipid metabolic process	IEA
0046890	involved_in regulation of lipid biosynthetic process	IBA
0046890	involved_in regulation of lipid biosynthetic process	ISS
0010866	involved_in regulation of triglyceride biosynthetic process	IEA
0009617	involved_in response to bacterium	IEA

Gene Loss events - THRSP (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0LSIE1	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_LLQRUN	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_QTVPPT	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_ULHU9J	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671