Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
SLC28A1 solute carrier family 28 member 1	CNT1 , HCNT1 , URCTU	Homo sapiens	29	protein-coding	SLC28A2 , SLC28A3		606207

Summary

Enables azole transmembrane transporter activity; cytidine transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in azole transmembrane transport; nucleoside transport; and pyrimidine-containing compound transmembrane transport. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
1901474	enables azole transmembrane transporter activity	IDA

Component (7)

Go ID	Value	Evidence
0016324	located_in apical plasma membrane	IDA
0031526	located_in brush border membrane	ISS
0005829	located_in cytosol	IDA
0016607	located_in nuclear speck	IDA
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	IDA
0005886	located_in plasma membrane	TAS

Process (12)

Go ID	Value	Evidence
0045117	involved_in azole transmembrane transport	IDA
0015861	involved_in cytidine transport	IBA
0015861	involved_in cytidine transport	IDA
0015861	involved_in cytidine transport	TAS
0180015	involved_in nucleoside import across plasma membrane	IMP
1901642	involved_in nucleoside transmembrane transport	IBA
1901642	involved_in nucleoside transmembrane transport	IDA
1904823	involved_in purine nucleobase transmembrane transport	NAS
0015855	involved_in pyrimidine nucleobase transport	IBA
0072531	involved_in pyrimidine-containing compound transmembrane transport	IDA
0015862	involved_in uridine transmembrane transport	IBA
0015862	involved_in uridine transmembrane transport	IDA

Gene Loss events - SLC28A1 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_CMGYA8	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_IAI08O	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_U5Z21Z	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_X9ZILC	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671