Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
SERPINB12 serpin family B member 12	YUKOPIN	Homo sapiens	12	protein-coding	SERPINA9 , SERPINA7 , SERPINA12 , SERPINA11 , SERPINA13P , SERPINA4 , SERPINA5 , SERPINA3 , SERPINA6 , SERPINA2 , SERPINA1 , AGT , SERPINA10 , SERPINC1 , SERPINF1 , SERPINH1 , SERPIND1 , SERPINE1 , SERPINI2 , SERPINI1 , SERPINF2 , SERPING1 , SERPINB8 , SERPINB9 , SERPINB6 , SERPINE2 , SERPINE3 , SERPINB5 , SERPINB13 , SERPINB3 , SERPINB4 , SERPINB2 , SERPINB10 , SERPINB7 , SERPINB11 , SERPINB1		615662

Summary

Enables serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0019899	enables enzyme binding	NAS

Component (6)

Go ID	Value	Evidence
0062023	located_in collagen-containing extracellular matrix	HDA
0001533	located_in cornified envelope	IEA
0005737	located_in cytoplasm	NAS
0005615	is_active_in extracellular space	IBA
0101003	located_in ficolin-1-rich granule membrane	TAS
0005886	located_in plasma membrane	TAS

Process (3)

Go ID	Value	Evidence
0002244	involved_in hematopoietic progenitor cell differentiation	IEA
0010951	involved_in negative regulation of endopeptidase activity	IBA
0042177	involved_in negative regulation of protein catabolic process	NAS

Gene Loss events - SERPINB12 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_I20JQA	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_LIDJMO	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_WY8VL6	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_Y2GL7X	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671