Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
QRFPR pyroglutamylated RFamide peptide receptor	AQ27 , GPR103 , SP9155	Homo sapiens	7	protein-coding	GNRHR , GNRHR2 , AVPR1B , AVPR1A , OXTR , AVPR2 , CCKAR , PROKR1 , PROKR2 , FFAR4 , HCRTR1 , HCRTR2 , GPR150 , GPR22 , NPFFR1 , NPFFR2		606925

Summary

Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in non-motile cilium. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IBA

Component (3)

Go ID	Value	Evidence
0016020	located_in membrane	IC
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	TAS

Process (4)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IBA
0007186	involved_in G protein-coupled receptor signaling pathway	IDA
0032870	involved_in cellular response to hormone stimulus	IBA
0007218	involved_in neuropeptide signaling pathway	IEA

Gene Loss events - QRFPR (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_DAZQYW	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_HGOG6J	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_NCCKPJ	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_XBEH2X	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671