Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
PPP3R2 protein phosphatase 3 regulatory subunit B, beta	PPP3RL	Homo sapiens	1	protein-coding		3.1.3.16	613821

Summary

Predicted to enable calcium ion binding activity and calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in sperm mitochondrial sheath. Predicted to be part of calcineurin complex. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005509	enables calcium ion binding	IEA

Component (6)

Go ID	Value	Evidence
0005955	part_of calcineurin complex	IBA
0005955	part_of calcineurin complex	NAS
0005829	located_in cytosol	NAS
0005739	located_in mitochondrion	IEA
0008287	part_of protein serine/threonine phosphatase complex	NAS
0097226	located_in sperm mitochondrial sheath	IEA

Process (6)

Go ID	Value	Evidence
0097720	involved_in calcineurin-mediated signaling	IBA
1905949	involved_in negative regulation of calcium ion import across plasma membrane	NAS
0007341	involved_in penetration of zona pellucida	IEA
0070886	involved_in positive regulation of calcineurin-NFAT signaling cascade	NAS
1905665	involved_in positive regulation of calcium ion import across plasma membrane	NAS
0006470	involved_in protein dephosphorylation	IBA

Gene Loss events - PPP3R2 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_8SLRCI	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_FHQ802	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_HDVOCD	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_YSSMBF	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671