Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
MGST2 microsomal glutathione S-transferase 2	GST2 , MGST-II	Homo sapiens	9	protein-coding	MGST3 , ALOX5AP , LTC4S	2.5.1.18 , 4.4.1.20	601733

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

GeneOntology

Function (1)

Go ID	Value	Evidence
0008047	enables enzyme activator activity	IEA

Component (6)

Go ID	Value	Evidence
0005783	is_active_in endoplasmic reticulum	IBA
0005789	located_in endoplasmic reticulum membrane	TAS
0043231	located_in intracellular membrane-bounded organelle	IDA
0016020	located_in membrane	IDA
0005635	is_active_in nuclear envelope	IBA
0005886	located_in plasma membrane	IDA

Process (9)

Go ID	Value	Evidence
0098869	involved_in cellular oxidant detoxification	IEA
0006750	involved_in glutathione biosynthetic process	IDA
0019370	involved_in leukotriene biosynthetic process	IBA
0019370	involved_in leukotriene biosynthetic process	IDA
0006629	involved_in lipid metabolic process	IDA
0046466	involved_in membrane lipid catabolic process	IDA
0050729	involved_in positive regulation of inflammatory response	NAS
0032496	involved_in response to lipopolysaccharide	IEA
0010243	involved_in response to organonitrogen compound	IEA

Gene Loss events - MGST2 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_DWVR0A	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_HLOYYZ	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_SUNPDO	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_XXFDCJ	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671