Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
IRGC immunity related GTPase cinema	IFGGE , IRGC1 , Iigp5 , CINEMA , R30953_1	Homo sapiens	3	protein-coding			620634

Summary

Predicted to enable GTPase activity. Predicted to be involved in cellular response to interferon-beta and defense response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005525	enables GTP binding	IEA

Component (4)

Go ID	Value	Evidence
0005811	located_in lipid droplet	IDA
0016020	located_in membrane	IEA
0036126	located_in sperm flagellum	IDA
0097226	located_in sperm mitochondrial sheath	IDA

Process (2)

Go ID	Value	Evidence
0098542	involved_in defense response to other organism	IEA
1902093	involved_in positive regulation of flagellated sperm motility	ISS

Gene Loss events - IRGC (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0U93VU	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_EBISEH	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_IZPRP1	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_QPQM9E	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671