Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6		Homo sapiens	23	protein-coding	SERGEF , HERC3 , RPGR , HERC5 , HERC4	2.3.2.26	609249

Summary

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0061630	enables ubiquitin protein ligase activity	IBA

Component (4)

Go ID	Value	Evidence
0005737	is_active_in cytoplasm	IBA
0005829	located_in cytosol	IDA
0005829	located_in cytosol	TAS
0005654	located_in nucleoplasm	IDA

Process (5)

Go ID	Value	Evidence
0002244	involved_in hematopoietic progenitor cell differentiation	IEA
0016567	involved_in protein ubiquitination	IBA
0016567	involved_in protein ubiquitination	IEA
0009617	involved_in response to bacterium	IEA
0006511	involved_in ubiquitin-dependent protein catabolic process	IBA

Gene Loss events - HERC6 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_JC9M38	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_OHGUEG	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_STTWVQ	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_UZAMN3	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671