Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
FFAR3 free fatty acid receptor 3	FFA3R , GPR41 , GPR42	Homo sapiens	2	protein-coding			603821

Summary

Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IBA

Component (3)

Go ID	Value	Evidence
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	IDA
0005886	located_in plasma membrane	TAS

Process (15)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IBA
0007186	involved_in G protein-coupled receptor signaling pathway	IDA
0007193	involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA
0071398	involved_in cellular response to fatty acid	IBA
0071398	involved_in cellular response to fatty acid	IDA
0006954	involved_in inflammatory response	IEA
0002385	involved_in mucosal immune response	ISS
0045776	involved_in negative regulation of blood pressure	ISS
0002879	involved_in positive regulation of acute inflammatory response to non-antigenic stimulus	ISS
0032722	involved_in positive regulation of chemokine production	ISS
0002720	involved_in positive regulation of cytokine production involved in immune response	ISS
0046885	involved_in regulation of hormone biosynthetic process	ISS
0046626	involved_in regulation of insulin receptor signaling pathway	ISS
0014061	involved_in regulation of norepinephrine secretion	ISS
0090276	involved_in regulation of peptide hormone secretion	ISS

Gene Loss events - FFAR3 (6 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_0XZWFT	Pteropus vampyrus	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1038/s41467-018-03667-1
GL_9RBDRC	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_BLY02F	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_MAJ0GZ	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_MZXF1V	Pteropus alecto	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1038/s41467-018-03667-1
GL_WVJZC8	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671