Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| CPA4 carboxypeptidase A4 | CPA3 | Homo sapiens | 12 | protein-coding | CPO , CPA6 , CPA3 , CPB1 , CPB2 , CPA5 , CPA1 , CPA2 | 3.4.17.15 | 607635 |
Summary
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
GeneOntology
Gene Loss events - CPA4 (4 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_DAZJLS | Orcinus orca | Artiodactyla | Other | Full | Cetacea | 10.1126/sciadv.aaw6671 |
| GL_HDZETW | Tursiops truncatus | Artiodactyla | Other | Full | Cetacea | 10.1126/sciadv.aaw6671 |
| GL_R3B4GQ | Physeter catodon | Artiodactyla | Other | Full | Cetacea | 10.1126/sciadv.aaw6671 |
| GL_UONPFL | Balaenoptera acutorostrata | Artiodactyla | Other | Full | Cetacea | 10.1126/sciadv.aaw6671 |