Gene Loss

Publication Details

Identifier: JB_Q1RBUA

Curator: Nádia Silva

DOI: 10.1007/s00251-019-01114-z

PMID: 31049641

Title:

Convergent inactivation of the skin-specific C-C motif chemokine ligand 27 in mammalian evolution.

Abstract:

The appearance of mammalian-specific skin features was a key evolutionary event contributing for the elaboration of physiological processes such as thermoregulation, adequate hydration, locomotion, and inflammation. Skin inflammatory and autoimmune processes engage a population of skin-infiltrating T cells expressing a specific C-C chemokine receptor (CCR10) which interacts with an epidermal CC chemokine, the skin-specific C-C motif chemokine ligand 27 (CCL27). CCL27 is selectively produced in the skin by keratinocytes, particularly upon inflammation, mediating the adhesion and homing of skin-infiltrating T cells. Here, we examined the evolution and coding condition of Ccl27 in 112 placental mammalian species. Our findings reveal that a number of open reading frame inactivation events such as insertions, deletions, and start and stop codon mutations independently occurred in Cetacea, Pholidota, Sirenia, Chiroptera, and Rodentia, totalizing 18 species. The diverse habitat settings and lifestyles of Ccl27-eroded lineages probably implied distinct evolutionary triggers rendering this gene unessential. For example, in Cetacea, the rapid renewal of skin layers minimizes the need for an elaborate inflammatory mechanism, mirrored by the absence of epidermal scabs. Our findings suggest that the convergent and independent loss of Ccl27 in mammalian evolution concurred with unique adaptive roads for skin physiology.

Last update:

03-07-2024

Associated Glosses (18 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_KICLDM	Lipotes vexillifer	CCL27	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_M5RAPP	Trichechus manatus	CCL27	LOF (frameshift, premature stop, ss)	Full	No	10.1007/s00251-019-01114-z
GL_PDB6KU	Manis javanica	CCL27	LOF (frameshift, premature stop, ss)	Full	No	10.1007/s00251-019-01114-z
GL_PGGPLF	Lagenorhynchus obliquidens	CCL27	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_PYB16U	Physeter catodon	CCL27	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_VZ15JI	Sousa chinensis	CCL27	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_XYMHGL	Delphinapterus leucas	CCL27	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z
GL_ZQZAKE	Orcinus orca	CCL27	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-019-01114-z