Gene Loss

Publication Details

Identifier: JB_CBH17H

Curator: Gonçalo Themudo

DOI: 10.1016/j.cub.2021.02.057

PMID: 33798433

Title:

Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos.

Abstract:

The macroevolutionary transition from terra firma to obligatory inhabitance of the marine hydrosphere has occurred twice in the history of Mammalia: Cetacea and Sirenia. In the case of Cetacea (whales, dolphins, and porpoises), molecular phylogenies provide unambiguous evidence that fully aquatic cetaceans and semiaquatic hippopotamids (hippos) are each other's closest living relatives. Ancestral reconstructions suggest that some adaptations to the aquatic realm evolved in the common ancestor of Cetancodonta (Cetacea + Hippopotamidae). An alternative hypothesis is that these adaptations evolved independently in cetaceans and hippos. Here, we focus on the integumentary system and evaluate these hypotheses by integrating new histological data for cetaceans and hippos, the first genome-scale data for pygmy hippopotamus, and comprehensive genomic screens and molecular evolutionary analyses for protein-coding genes that have been inactivated in hippos and cetaceans. We identified eight skin-related genes that are inactivated in both cetaceans and hippos, including genes that are related to sebaceous glands, hair follicles, and epidermal differentiation. However, none of these genes exhibit inactivating mutations that are shared by cetaceans and hippos. Mean dates for the inactivation of skin genes in these two clades serve as proxies for phenotypic changes and suggest that hair reduction/loss, the loss of sebaceous glands, and changes to the keratinization program occurred ∼16 Ma earlier in cetaceans (∼46.5 Ma) than in hippos (∼30.5 Ma). These results, together with histological differences in the integument and prior analyses of oxygen isotopes from stem hippopotamids ("anthracotheres"), support the hypothesis that aquatic skin adaptations evolved independently in hippos and cetaceans.

Last update:

28-10-2024

Associated Glosses (230 results)

GlossID	Species	Symbol	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_1ZJMVP	Balaenoptera acutorostrata	TSPYL6	Other	Full	No	10.1016/j.cub.2021.02.057
GL_20K0EU	Balaenoptera acutorostrata	ABCA10	Other	Full	No	10.1016/j.cub.2021.02.057
GL_24SS4H	Physeter catodon	MRGPRX2	Other	Full	No	10.1016/j.cub.2021.02.057
GL_2FJKRZ	Balaenoptera acutorostrata	CES3	Other	Full	No	10.1016/j.cub.2021.02.057
GL_2LHGOG	Hippopotamus amphibius	ALOX15	LOF (frameshift, premature stop, ss)	Full	Hippopotamidae	10.1016/j.cub.2021.02.057
GL_2NMBVB	Tursiops truncatus	CES3	Other	Full	No	10.1016/j.cub.2021.02.057
GL_3J2WRP	Physeter catodon	TSPYL6	Other	Full	No	10.1016/j.cub.2021.02.057
GL_3MT9MC	Delphinapterus leucas	KRTAP7-1	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.02.057
GL_3PIDWQ	Physeter catodon	TAS2R60	Other	Full	No	10.1016/j.cub.2021.02.057
GL_4M0ONI	Hexaprotodon liberiensis	AWAT1	LOF (frameshift, premature stop, ss)	Full	Hippopotamidae	10.1016/j.cub.2021.02.057