Ψ TPSAB1 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_XWHIKO | Physeter catodon | Other | Full | No | Multiple individual SRA |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Methodology & Validation | "To further ensure that assembly artifacts are not mistaken for gene losses, we used the Trace Archive Nucleotide BLAST to search inside RNA-Seq sets SRX220358, SRX220357, SRX220356, SRX220355, SRX220354, SRX220353, SRX220352, SRX220351 and SRX220350." | 10.1093/gbe/evx187 |
| Phenotypic | "A loss of several proteases in cetaceans suggests a trend towards a milder inflammatory response relevant to Peto’s paradox: A theory postulated to explain the lower relative incidence of cancer in large mammals (CaulinandMaley2011)." | 10.1093/gbe/evx187 |
| Other | "Other proteases, such as TPSAB1 and MASP2 (Figure 1), seem to have been lost in several cetaceans independently." | 10.1093/gbe/evx187 |
Curator Observations
See supplementary material for more details. Authors indicate this gene is also lost other cetacea, but do not provide further details.