Ψ TCHHL1 - Hippopotamus amphibius
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_UAA3JE | Hippopotamus amphibius | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | ""8D (exon 1) 118-120P (exon 1) 700-702P (exon 2) 1915-1917P (exon 3) 2509D (exon 2)" D = deletion, I = insertion, P = premature stop codon, S = start codon mutation, M = mutated stop codon." | 10.1016/j.cub.2021.02.057 |
| Other | ""In particular, the hippo epidermis is much thinner, has shallower rete ridges, and partially preserves epidermal barrier function as hippos spend substantial time on land. These differences may explain why only one EDC gene, TCHHL1 (trichohyalin-like 1), is convergently inactivated in cetaceans and hippos"" | 10.1016/j.cub.2021.02.057 |
Curator Observations
See Supplementary Table 2 for details regarding inactivating mutations.