Ψ ALOX15 - Physeter catodon

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_SY0N3W Physeter catodon LOF (frameshift, premature stop, ss) Full Yes Genomic XM_007109201.2 

Statements

Type Excerpt DOI
Mutation Description ""The distribution of mutations in ALOX15 suggests that it was independently inactivated on three different cetacean branches."" 10.1016/j.cub.2021.02.057
Timing of Loss "21.44 MA" 10.1016/j.cub.2021.02.057
Phenotypic ""ALOX15 (arachidonate 15-lipoxygenase) belongs to the lipoxygenase family of enzymes that catalyze bioactive lipids synthesis, including resolvins that regulate resolution of excessive inflammatory responses. ALOX15 is highly expressed in mouse epidermis, and Axol15/ mutant mouse studies suggest a role in epidermal barrier function."" 10.1016/j.cub.2021.02.057
Other ""ALOX15, that are independently inactivated in cetaceans and hippos"" 10.1016/j.cub.2021.02.057

Curator Observations

See Table 2 for details regarding timing of loss. See Supplementary Table 2 for details regarding inactivating mutations