Ψ SEC14L3 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_QPZZAW | Physeter catodon | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "The second lung-expressed gene SEC14L3 is expressed in airway ciliated cells and in alveolar type II cells that secrete pulmonary surfactant, the lipid-protein complex that prevents alveoli collapse (44, 45)." | 10.1126/sciadv.aaw6671 |
| Functional | "SEC14L3 functions as a sensor of liposomal lipid-packing defects and may affect surfactant composition (45)." | 10.1126/sciadv.aaw6671 |
| Phenotypic | "Alterations in surfactant composition may be relevant for cetaceans and other diving mammals. A study in seals suggested that pulmonary surfactants with anti-adhesive properties are important for diving mammals by facilitating alveolar reinflation after collapse (46)." | 10.1126/sciadv.aaw6671 |
Curator Observations
Authors identified a conserved mutation in the 5´ splice site of exon 7.