Ψ OXCT2 - Monodon monoceros
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_OYKC2V | Monodon monoceros | Exon(s) deletion | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Together, most of these metabolic steps are controlled by sperm-restricted gene orthologs, including (...) the 3-Oxoacid CoA-transferase 2 (Oxct2), which converts ketone-body-derived acetoacetate into acetoacetyl-CoA in sperm cells (Figure 2).24 We examined each gene ortholog sequence in various mammal species and found ORF-disrupting mutations or exon-loss events in most cetacean species (Figure 2; figshare link in Key resources table)." | 10.1016/j.cub.2021.05.062 |
Curator Observations
This gene is duplicated in Cetacea. The second copy in M. monoceros is also missing.