Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide | ADH-2 , HEL-S-4 | Homo sapiens | 10 | protein-coding | ADH7 , ADH6 , ADH1C , ADH1B , ADH1A , ADH5 | 1.1.1.105 | 103740 |
Summary
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
GeneOntology
Gene Loss events - ADH4 (4 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_6AKY2M | Orcinus orca | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1126/sciadv.aaw6671 |
| GL_8AJYNF | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1126/sciadv.aaw6671 |
| GL_BRVBDE | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1126/sciadv.aaw6671 |
| GL_PQTXXE | Tursiops truncatus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1126/sciadv.aaw6671 |