Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TREM1 triggering receptor expressed on myeloid cells 1	CD354 , TREM-1	Homo sapiens	6	protein-coding			605085

Summary

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneOntology

Function (1)

Go ID	Value	Evidence
0097110	enables scaffold protein binding	IPI

Component (3)

Go ID	Value	Evidence
0009986	is_active_in cell surface	IDA
0005576	located_in extracellular region	IEA
0005886	located_in plasma membrane	TAS

Process (8)

Go ID	Value	Evidence
0002250	involved_in adaptive immune response	IEA
0032602	involved_in chemokine production	IBA
0002367	involved_in cytokine production involved in immune response	IBA
0006959	involved_in humoral immune response	TAS
0045087	involved_in innate immune response	IEA
0035556	involved_in intracellular signal transduction	TAS
0030593	involved_in neutrophil chemotaxis	IBA
0070945	involved_in neutrophil-mediated killing of gram-negative bacterium	IBA

Gene Loss events - TREM1 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_9JNJQD	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_GO0YAH	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_IAANHP	Physeter catodon	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671
GL_NTOWX0	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1126/sciadv.aaw6671