Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| SLURP1 secreted LY6/PLAUR domain containing 1 | ARS , MDM , ANUP , ArsB , LY6LS , LY6-MT | Homo sapiens | 3 | N/a | 606119 |
Summary
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
Gene Loss events - SLURP1 (4 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_6QVP8L | Manis crassicaudata | Pholidota | Other | Undetermined | No | 10.1007/s00239-023-10118-z |
| GL_CZMPFQ | Phataginus tricuspis | Pholidota | LOF (frameshift, premature stop, ss) | Full | No | 10.1007/s00239-023-10118-z |
| GL_GAA8WC | Manis pentadactyla | Pholidota | Exon(s) deletion | Full | No | 10.1007/s00239-023-10118-z |
| GL_IINGJ6 | Manis javanica | Pholidota | Exon(s) deletion | Full | No | 10.1007/s00239-023-10118-z |