Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
IL20 interleukin 20	IL-20 , IL10D , ZCYTO10	Homo sapiens	8	protein-coding	IL10 , IL26 , IL24 , IL19		605619

Summary

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

Knockout

Increased circulating alanine transaminase level. Decreased startle reflex.

Mouse Phenotype Database

GeneOntology

Function (1)

Go ID	Value	Evidence
0005125	enables cytokine activity	IEA

Component (2)

Go ID	Value	Evidence
0005576	located_in extracellular region	TAS
0005615	located_in extracellular space	IEA

Process (7)

Go ID	Value	Evidence
0030316	involved_in osteoclast differentiation	IEA
0045606	involved_in positive regulation of epidermal cell differentiation	TAS
0045618	involved_in positive regulation of keratinocyte differentiation	TAS
0045672	involved_in positive regulation of osteoclast differentiation	IEA
0042531	involved_in positive regulation of tyrosine phosphorylation of STAT protein	TAS
0050727	involved_in regulation of inflammatory response	TAS
0007165	involved_in signal transduction	IEA

Gene Loss events - IL20 (11 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_ZZS4CA	Balaenoptera bonaerensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1007/s00251-018-1071-5