Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
MYO9A myosin IXA	CMS24	Homo sapiens	47	protein-coding			604875

Summary

This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (7)

Go ID	Value	Evidence
0005884	is_active_in actin filament	IBA
0044295	is_active_in axonal growth cone	IBA
0044295	located_in axonal growth cone	ISS
0005829	located_in cytosol	TAS
0016020	located_in membrane	IEA
0045202	located_in synapse	IEA
0016461	part_of unconventional myosin complex	NAS

Process (8)

Go ID	Value	Evidence
0034329	involved_in cell junction assembly	IMP
0045198	involved_in establishment of epithelial cell apical/basal polarity	IBA
0045198	involved_in establishment of epithelial cell apical/basal polarity	IMP
0035556	involved_in intracellular signal transduction	IEA
0043547	involved_in positive regulation of GTPase activity	IEA
0150011	involved_in regulation of neuron projection arborization	ISS
0051056	involved_in regulation of small GTPase mediated signal transduction	TAS
0007601	involved_in visual perception	TAS

Gene Loss events - MYO9A (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_N2UV2R	Odobenus rosmarus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004