Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| AWAT2 acyl-CoA wax alcohol acyltransferase 2 | WS , DC4 , ARAT , MFAT , DGAT2L4 | Homo sapiens | 8 | DGAT2L6, DGAT2, MOGAT3, MOGAT2, MOGAT1, AWAT1 | 2.3.1.75 , 2.3.1.76 | 300925 |
Summary
This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]
GeneOntology
Gene Loss events - AWAT2 (16 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_RBOIH1 | Phataginus tricuspis | Pholidota | LOF (frameshift, premature stop, ss) | Full | No | 10.1007/s00239-023-10118-z |
| GL_V2BZCU | Trichechus manatus latirostris | Sirenia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/molbev/msz068 |
| GL_WN5DOA | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/molbev/msz068 |
| GL_XF9SA1 | Eschrichtius robustus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/molbev/msz068 |
| GL_XIQAIH | Delphinapterus leucas | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/molbev/msz068 |
| GL_Z85VN8 | Sus scrofa | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/molbev/msz068 |