Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
MYO3B myosin IIIB		Homo sapiens	43	protein-coding		2.7.11.1	610040

Summary

This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (6)

Go ID	Value	Evidence
0005737	located_in cytoplasm	IEA
0032433	is_active_in filopodium tip	IBA
0016459	part_of myosin complex	IEA
0001917	is_active_in photoreceptor inner segment	IBA
0032426	is_active_in stereocilium tip	IBA
0032426	located_in stereocilium tip	ISS

Process (8)

Go ID	Value	Evidence
0006338	involved_in chromatin remodeling	IEA
0090103	involved_in cochlea morphogenesis	ISS
0051491	involved_in positive regulation of filopodium assembly	IBA
0006468	involved_in protein phosphorylation	IEA
0030832	involved_in regulation of actin filament length	IBA
0007605	involved_in sensory perception of sound	IBA
0007605	involved_in sensory perception of sound	ISS
0007601	involved_in visual perception	IEA

Gene Loss events - MYO3B (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_GMZVBU	Dasypus novemcinctus	Cingulata	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004