Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TACSTD2 tumor associated calcium signal transducer 2	EGP1 , GP50 , M1S1 , EGP-1 , TROP2 , GA7331 , GA733-1	Homo sapiens	1	protein-coding			137290

Summary

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005515	enables protein binding	IPI

Component (7)

Go ID	Value	Evidence
0009925	located_in basal plasma membrane	ISS
0005829	located_in cytosol	TAS
0070062	located_in extracellular exosome	HDA
0005615	is_active_in extracellular space	IBA
0016328	located_in lateral plasma membrane	ISS
0016020	located_in membrane	TAS
0005634	is_active_in nucleus	IBA

Process (10)

Go ID	Value	Evidence
0090191	involved_in negative regulation of branching involved in ureteric bud morphogenesis	ISS
2000146	involved_in negative regulation of cell motility	ISS
0010633	involved_in negative regulation of epithelial cell migration	ISS
1900028	involved_in negative regulation of ruffle assembly	ISS
0051497	involved_in negative regulation of stress fiber assembly	ISS
1900025	involved_in negative regulation of substrate adhesion-dependent cell spreading	ISS
2000738	involved_in positive regulation of stem cell differentiation	IBA
0050678	involved_in regulation of epithelial cell proliferation	IEA
0060675	involved_in ureteric bud morphogenesis	IEA
0007601	involved_in visual perception	IEA

Gene Loss events - TACSTD2 (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_FARKP8	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004