Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
ACTBL2 actin beta like 2	ACT	Homo sapiens	1	protein-coding	ACTR5 , ACTR6 , ACTR3B , ACTR3 , ACTG2 , ACTA2 , ACTC1 , ACTA1 , ACTL10 , ACTRT1 , ACTRT2 , ACTRT3 , ACTL9 , ACTG1 , ACTL8 , POTEKP , POTEF , POTEI , POTEJ , POTEE , ACTB , ACTL6B , ACTL6A , ACTR8 , ACTR1A , ACTR1B , ACTR10 , ACTL7B , ACTL7A , ACTR2		614835

Summary

Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (9)

Go ID	Value	Evidence
0035267	part_of NuA4 histone acetyltransferase complex	IBA
0015629	is_active_in actin cytoskeleton	IBA
0005884	is_active_in actin filament	IBA
0030424	is_active_in axon	IBA
0005737	is_active_in cytoplasm	IBA
0070062	located_in extracellular exosome	HDA
0005615	located_in extracellular space	HDA
0098978	is_active_in glutamatergic synapse	IBA
0016020	is_active_in membrane	IBA

Process (4)

Go ID	Value	Evidence
0007409	involved_in axonogenesis	IBA
0008150	involved_in biological_process	ND
0048870	involved_in cell motility	IBA
0098974	involved_in postsynaptic actin cytoskeleton organization	IEA

Gene Loss events - ACTBL2 (5 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_DPOJC7	Physeter catodon	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_EU2H71	Tursiops truncatus	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_FJDYTO	Orcinus orca	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_N2JDMO	Hippopotamus amphibius	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057
GL_RW8Y6C	Balaenoptera acutorostrata	Artiodactyla	Other	Full	No	10.1016/j.cub.2021.02.057