Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
ALOX15 arachidonate 15-lipoxygenase LOG15 , 12-LOX , 15-LOX , 15-LOX-1 Homo sapiens 14 protein-coding ALOX12B , ALOX15B , ALOXE3 , ALOX5 , ALOX12 1.13.11.12 , 1.13.11.31 , 1.13.11.33 152392

Summary

This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

GeneOntology

Gene Loss events - ALOX15 (6 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_2LHGOG Hippopotamus amphibius Artiodactyla LOF (frameshift, premature stop, ss) Full Hippopotamidae 10.1016/j.cub.2021.02.057
GL_DRNF3V Hexaprotodon liberiensis Artiodactyla LOF (frameshift, premature stop, ss) Full Hippopotamidae 10.1016/j.cub.2021.02.057
GL_JBD0RX Balaenoptera acutorostrata Artiodactyla LOF (frameshift, premature stop, ss) Full 10.1016/j.cub.2021.02.057
GL_NMLPOA Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full 10.1016/j.cub.2021.02.057
GL_SY0N3W Physeter catodon Artiodactyla LOF (frameshift, premature stop, ss) Full 10.1016/j.cub.2021.02.057
GL_YBSZRU Orcinus orca Artiodactyla LOF (frameshift, premature stop, ss) Full 10.1016/j.cub.2021.02.057