Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
KRT77 keratin 77	K1B , KRT1B	Homo sapiens	10	protein-coding	KRT8 , KRT6C , KRT6B , KRT6A , KRT80 , KRT74 , KRT71 , KRT72 , KRT73 , KRT78 , KRT4 , KRT79 , KRT76 , KRT3 , KRT2 , KRT1 , KRT75 , KRT5 , KRT85 , KRT86 , KRT81 , KRT83 , KRT84 , KRT82 , KRT7		611158

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneOntology

Function (1)

Go ID	Value	Evidence
0003674	enables molecular_function	ND

Component (5)

Go ID	Value	Evidence
0001533	located_in cornified envelope	IEA
0005856	located_in cytoskeleton	IDA
0005829	located_in cytosol	TAS
0070062	located_in extracellular exosome	HDA
0045095	is_active_in keratin filament	IBA

Process (3)

Go ID	Value	Evidence
0008150	involved_in biological_process	ND
0045109	involved_in intermediate filament organization	IBA
0031424	involved_in keratinization	IBA

Gene Loss events - KRT77 (12 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_UQKCVO	Physeter catodon	Artiodactyla	Gene deletion	Full	Cetacea	10.1016/j.cub.2021.02.057
GL_XP0UAN	Lipotes vexillifer	Artiodactyla	Gene deletion	Full	No	10.1186/s12983-017-0225-x