Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
KRT85 keratin 85	HB5 , K85 , Hb-5 , hHb5 , ECTD4 , KRTHB5	Homo sapiens	10	protein-coding	KRT8 , KRT6C , KRT6B , KRT6A , KRT80 , KRT74 , KRT71 , KRT72 , KRT73 , KRT77 , KRT78 , KRT4 , KRT79 , KRT76 , KRT3 , KRT2 , KRT1 , KRT75 , KRT5 , KRT86 , KRT81 , KRT83 , KRT84 , KRT82 , KRT7		602767

Summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005515	enables protein binding	IPI

Component (3)

Go ID	Value	Evidence
0005829	located_in cytosol	TAS
0005615	located_in extracellular space	HDA
0045095	is_active_in keratin filament	IBA

Process (3)

Go ID	Value	Evidence
0008544	involved_in epidermis development	TAS
0045109	involved_in intermediate filament organization	IBA
0031424	involved_in keratinization	IBA

Gene Loss events - KRT85 (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_RTDSKE	Neophocaena asiaeorientalis asiaeorientalis	Artiodactyla	Other	Full	No	10.1186/s12983-017-0225-x