Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
KRT7 keratin 7	K7 , CK7 , SCL , K2C7	Homo sapiens	11	protein-coding	KRT8 , KRT6C , KRT6B , KRT6A , KRT80 , KRT74 , KRT71 , KRT72 , KRT73 , KRT77 , KRT78 , KRT4 , KRT79 , KRT76 , KRT3 , KRT2 , KRT1 , KRT75 , KRT5 , KRT85 , KRT86 , KRT81 , KRT83 , KRT84 , KRT82		148059

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005515	enables protein binding	IPI

Component (8)

Go ID	Value	Evidence
0005737	located_in cytoplasm	IDA
0005829	located_in cytosol	IDA
0005829	located_in cytosol	TAS
0070062	located_in extracellular exosome	HDA
0005882	located_in intermediate filament	NAS
0045111	located_in intermediate filament cytoskeleton	IDA
0045095	is_active_in keratin filament	IBA
0005634	located_in nucleus	HDA

Process (2)

Go ID	Value	Evidence
0045109	involved_in intermediate filament organization	IBA
0031424	involved_in keratinization	IBA

Gene Loss events - KRT7 (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_AOGZE4	Balaena mysticetus	Artiodactyla	Other	Full	No	10.1186/s12983-017-0225-x