Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
OXCT2 3-oxoacid CoA-transferase 2	SCOTT , FKSG25	Homo sapiens	1	protein-coding		2.8.3.5	610289

Summary

The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]

GeneOntology

Function (1)

Go ID	Value	Evidence
0008260	enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IBA

Component (4)

Go ID	Value	Evidence
0005759	located_in mitochondrial matrix	TAS
0005739	is_active_in mitochondrion	IBA
0005739	located_in mitochondrion	IDA
0031514	located_in motile cilium	IDA

Process (2)

Go ID	Value	Evidence
0046950	involved_in cellular ketone body metabolic process	IBA
0046952	involved_in ketone body catabolic process	IEA

Gene Loss events - OXCT2 (17 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_FJAAJJ	Balaenoptera musculus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_JHHPBK	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_MVC9NG	Balaena mysticetus	Artiodactyla	Exon(s) deletion	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_OE2CPS	Globicephala melas	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_OYKC2V	Monodon monoceros	Artiodactyla	Exon(s) deletion	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_VDD6SK	Sousa chinensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_XIGFNT	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062