Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| KRT83 keratin 83 | HB3 , Hb-3 , EKVP5 , MNLIX , KRTHB3 | Homo sapiens | 9 | protein-coding | KRT8 , KRT6C , KRT6B , KRT6A , KRT80 , KRT74 , KRT71 , KRT72 , KRT73 , KRT77 , KRT78 , KRT4 , KRT79 , KRT76 , KRT3 , KRT2 , KRT1 , KRT75 , KRT5 , KRT85 , KRT86 , KRT81 , KRT84 , KRT82 , KRT7 | 602765 |
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]
GeneOntology
Gene Loss events - KRT83 (6 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_5LC6R5 | Orcinus orca | Artiodactyla | Other | Full | No | 10.1186/s12983-017-0225-x |
| GL_OCARPZ | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1186/1471-2164-15-869 |
| GL_TIKBCH | Tursiops truncatus | Artiodactyla | Other | Full | No | 10.1186/s12983-017-0225-x |
| GL_UZG2TE | Physeter catodon | Artiodactyla | Gene deletion | Full | No | 10.1186/s12983-017-0225-x |
| GL_XGO4QT | Tursiops truncatus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1186/1471-2164-15-869 |
| GL_XSRSRU | Neophocaena asiaeorientalis asiaeorientalis | Artiodactyla | Other | Full | No | 10.1186/s12983-017-0225-x |