Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
ENAM enamelin ADAI , AI1C , AIH2 Homo sapiens 9 protein-coding 606585

Summary

Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]

GeneOntology

Gene Loss events - ENAM (20 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_DPEEVL Eubalaena australis Artiodactyla LOF (frameshift, premature stop, ss) Full Eubalaena 10.1371/journal.pgen.1000634
GL_I5H2OL Phataginus tricuspis Pholidota LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_JFRTIF Myrmecophaga tridactyla Pilosa LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_MCMQ5B Tamandua tetradactyla Pilosa LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_NAZYZP Cyclopes didactylus Pilosa LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_NPKY3F Manis pentadactyla Pholidota LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_OKTVLH Choloepus hoffmanni Pilosa LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_PEHZZT Euphractus sexcinctus Cingulata LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_QQIFMW Chaetophractus villosus Cingulata LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634
GL_TWOZXQ Megaptera novaeangliae Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1371/journal.pgen.1000634