Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
TAS1R2 taste 1 receptor member 2	TR2 , T1R2 , GPR71	Homo sapiens	6	protein-coding	GPRC6A , TAS1R1 , TAS1R3 , CASR		606226

Summary

Contributes to sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet taste receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IBA

Component (6)

Go ID	Value	Evidence
0016020	located_in membrane	IC
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	TAS
0043235	part_of receptor complex	IDA
1903767	part_of sweet taste receptor complex	IBA
1903767	part_of sweet taste receptor complex	IDA

Process (5)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IC
0001582	involved_in detection of chemical stimulus involved in sensory perception of sweet taste	IDA
0032467	involved_in positive regulation of cytokinesis	IMP
0050916	involved_in sensory perception of sweet taste	IBA
0050916	involved_in sensory perception of sweet taste	IDA

Gene Loss events - TAS1R2 (15 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_PNHWCB	Neophocaena phocaenoides	Artiodactyla	LOF (frameshift, premature stop, ss)	Full		10.1186/s12862-014-0218-8
GL_SPFYSA	Phoca vitulina	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109
GL_TUQTWF	Lipotes vexillifer	Artiodactyla	LOF (frameshift, premature stop, ss)	Full		10.1186/s12862-014-0218-8
GL_VFB3KG	Arctocephalus forsteri	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109
GL_XV4R7K	Aonyx cinereus	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1073/pnas.1118360109