Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GK2 glycerol kinase 2	GKP2 , GKTA	Homo sapiens	1	protein-coding		2.7.1.30	600148

Summary

Predicted to enable glycerol kinase activity. Predicted to be involved in several processes, including glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Knockout

male infertility

Mouse Phenotype Database

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (5)

Go ID	Value	Evidence
0070062	located_in extracellular exosome	HDA
0005741	located_in mitochondrial outer membrane	ISS
0005739	is_active_in mitochondrion	IBA
0097225	located_in sperm midpiece	IDA
0097226	located_in sperm mitochondrial sheath	ISS

Process (8)

Go ID	Value	Evidence
0030317	involved_in flagellated sperm motility	ISS
0019563	involved_in glycerol catabolic process	IEA
0006071	involved_in glycerol metabolic process	IBA
0046167	involved_in glycerol-3-phosphate biosynthetic process	IBA
0016310	involved_in phosphorylation	IBA
0120317	involved_in sperm mitochondrial sheath assembly	ISS
0007283	involved_in spermatogenesis	ISS
0006641	involved_in triglyceride metabolic process	IBA

Gene Loss events - GK2 (14 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_VVBDRP	Tursiops aduncus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_XU5PPX	Suricata suricatta	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.cub.2021.05.062
GL_YMBQ5G	Orcinus orca	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062
GL_YZKN1E	Sousa chinensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Delphinidae	10.1016/j.cub.2021.05.062