Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
PTGR1 prostaglandin reductase 1	PGR1 , DIG-1 , ZADH3 , LTB4DH	Homo sapiens	14	protein-coding		1.3.1.48 , 1.3.1.74	601274

Summary

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneOntology

Function (1)

Go ID	Value	Evidence
0036185	enables 13-lipoxin reductase activity	ISS

Component (2)

Go ID	Value	Evidence
0005737	located_in cytoplasm	ISS
0070062	located_in extracellular exosome	HDA

Process (5)

Go ID	Value	Evidence
0036102	involved_in leukotriene B4 metabolic process	ISS
0006691	involved_in leukotriene metabolic process	NAS
2001302	involved_in lipoxin A4 metabolic process	ISS
0006693	involved_in prostaglandin metabolic process	IBA
0006693	involved_in prostaglandin metabolic process	IDA

Gene Loss events - PTGR1 (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_DZJCTG	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_H8NOX2	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_KUS64K	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_QWERR5	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671