Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
IL31RA interleukin 31 receptor A	CRL , GPL , CRL3 , GLMR , GLM-R , PLCA2 , hGLM-R , IL-31RA , PRO21384 , zcytoR17	Homo sapiens	20	protein-coding	CRLF1 , OSMR , LIFR , IL12RB2 , IL12RB1 , IL23R , PRLR , CRLF2 , CSF2RA , GHR , IL6ST , CSF3R , IL6R , IL11RA , CNTFR , LEPR , IL3RA , IL5RA , IL13RA2		609510

Summary

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneOntology

Function (1)

Go ID	Value	Evidence
0019955	enables cytokine binding	IBA

Component (6)

Go ID	Value	Evidence
0030424	located_in axon	IEA
0009897	is_active_in external side of plasma membrane	IBA
0016020	located_in membrane	NAS
0005886	located_in plasma membrane	TAS
0042734	located_in presynaptic membrane	IEA
0043235	part_of receptor complex	IBA

Process (17)

Go ID	Value	Evidence
0000165	involved_in MAPK cascade	NAS
0002438	involved_in acute inflammatory response to antigenic stimulus	IEA
0007169	involved_in cell surface receptor protein tyrosine kinase signaling pathway	NAS
0007259	involved_in cell surface receptor signaling pathway via JAK-STAT	IEP
0019221	involved_in cytokine-mediated signaling pathway	IBA
0019221	involved_in cytokine-mediated signaling pathway	TAS
0006952	involved_in defense response	NAS
0098542	involved_in defense response to other organism	IEA
0002067	involved_in glandular epithelial cell differentiation	IEA
0042592	involved_in homeostatic process	NAS
0030225	involved_in macrophage differentiation	NAS
0030224	involved_in monocyte differentiation	IEP
0043066	involved_in negative regulation of apoptotic process	NAS
0043031	involved_in negative regulation of macrophage activation	NAS
0045893	involved_in positive regulation of DNA-templated transcription	NAS
0008284	involved_in positive regulation of cell population proliferation	IDA
0042531	involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEP

Gene Loss events - IL31RA (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_9LMEGA	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_JHNY1G	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_OZ5Z7Y	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_URTRLW	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671