Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
FCGR1A Fc gamma receptor Ia	CD64 , FCG1 , FCRI , CD64A , FCGR1 , IGFR1 , FcgammaRI	Homo sapiens	8	protein-coding	PECAM1 , C17orf99 , MILR1 , FCER1A , FCRLB , FCGR3B , FCGR2A , FCGR2B , FCGR2C , FCRL2 , FCRL6 , FCRL3 , FCRL5 , FCRLA , FCRL1 , FCRL4		146760

Summary

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0019864	enables IgG binding	IEA

Component (5)

Go ID	Value	Evidence
0030669	located_in clathrin-coated endocytic vesicle membrane	TAS
0031901	located_in early endosome membrane	TAS
0009897	is_active_in external side of plasma membrane	IBA
0005886	located_in plasma membrane	IDA
0005886	located_in plasma membrane	TAS

Process (15)

Go ID	Value	Evidence
0038094	involved_in Fc-gamma receptor signaling pathway	IMP
0001788	involved_in antibody-dependent cellular cytotoxicity	IBA
0001788	involved_in antibody-dependent cellular cytotoxicity	IDA
0042590	involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I	IEA
0007166	involved_in cell surface receptor signaling pathway	IBA
0042742	involved_in defense response to bacterium	IEA
0006955	involved_in immune response	TAS
0045087	involved_in innate immune response	IEA
0006911	involved_in phagocytosis, engulfment	IEA
0006910	involved_in phagocytosis, recognition	IEA
0050766	involved_in positive regulation of phagocytosis	IEA
0001805	involved_in positive regulation of type III hypersensitivity	IEA
0001798	involved_in positive regulation of type IIa hypersensitivity	IEA
0006898	involved_in receptor-mediated endocytosis	IEA
0007165	involved_in signal transduction	TAS

Gene Loss events - FCGR1A (4 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_JKQWMZ	Tursiops truncatus	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_JXSZNA	Orcinus orca	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_QKTOD5	Balaenoptera acutorostrata	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671
GL_RP1YFK	Physeter catodon	Artiodactyla	Other	Full	Cetacea	10.1126/sciadv.aaw6671